PREDATOR can protect several PCs with the same USB lock usb flash drive, e.g. your home and office computers.
TrueCrypt also has the ability to use ‘ keyfiles ‘ as additional keys needed to decrypt a disk image. A key file can be any file on your computer, MP3, PDF, ZIP. Preferably this should be a file that is not going to change, usb security so don’t use some text file that you edit on a regular basis. As this disk image will reside on your USB drive, the keyfile will also need to be on the drive if you want to be able to mount this image whilst on the move.
If you want the host system to simply not accept any mass storage device hardware over any USB port, protect usb Suite can easily block access to the drives when inserted and, only when a password you set beforehand is provided, can the USB ports be re-enabled for use with flash drives. This arguably is more convenient than turning off USB ports at the BIOS level, which would also have the added repercussion of disabling input devices as well. A UAC prompt will appear anytime the block is enabled or disabled. Just as a fair warning, any password you do set blanks out after a system reboot, necessitating a password reset to resume the secure function.